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Welcome to the Lockn' Forum - The home of the original Lockn' Music Festival family!
Please note: This forum is in no way officially associated with Lockn' Festival or its promoters.
Recent Posts
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 20, 2024 9:30:53 GMT -5
Birthday run in Vegas?
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 15, 2024 11:07:45 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 15, 2024 9:33:34 GMT -5
<<inset beating dead horse gif here>>
No one in DSO was in the Grateful Dead but it matters not. They play the music that I like to hear live. Hell DSO could play Allman Brothers music and I'd go listen...
Don't make me lock this thread...
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 14, 2024 21:41:23 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 13, 2024 14:02:10 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 13, 2024 12:21:32 GMT -5
Semantics. Good for debate when there's nothing else.
Also, Les Dudek is the second guitar on Brothers and Sisters--is he a bro?
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 12, 2024 17:51:21 GMT -5
re·un·ion
/rēˈyo͞onyən/
noun
an instance of two or more people coming together again after a period of separation.
"she had a tearful reunion with her parents"
a social gathering attended by members of a certain group of people who have not seen each other for some time.
"a school reunion"
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 12, 2024 6:29:23 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 11, 2024 11:14:01 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 7, 2024 8:37:49 GMT -5
A clinical trial’s encouraging results won US Food and Drug Administration breakthrough therapy status for an LSD formulation to treat generalized anxiety disorder, Mind Medicine Inc. announced Thursday. The biopharmaceutical company is developing the drug.
“A breakthrough designation is a recognition that a drug has demonstrated evidence of clinical efficacy in meeting an unmet medical need with morbidity and mortality associated with it,” said Dr. Daniel Karlin, assistant professor of psychiatry at Tufts University School of Medicine in Boston and chief medical officer for MindMed.
MindMed’s MM120 will still go through the standard FDA approval process, including phase III trials.
The designation, however, “is an offer from the agency to engage more closely in drug development,” Karlin said. “It affects timelines of response and our ability to get more interactions with the agency so that we can be sure that we’re in lockstep agreement as we move forward.”
Two other companies have also received FDA breakthrough therapy status: psilocybin for treatment-resistant depression and to MDMA, (3,4-Methylenedioxymethamphetamine) commonly known as ecstasy or molly, for post-traumatic stress disorder or PTSD.
New results on efficacy at 12 weeks
A single dose of MM120 (lysergide d-tartrate) led to a 48% rate of remission from generalized anxiety disorder at 12 weeks following the drug’s administration, according to MindMed.
The MM120 drug also significantly improved clinical signs of generalized anxiety disorder for 65% of patients within three months, according to results of the phase 2b trial designed to test dosage levels, the company said.
Anxiety is the most common mental disorder in the United States, affecting over 40 million people age 18 and older each year, according to the Anxiety and Depression Association of America. Generalized anxiety order is characterized by excessive, ongoing thoughts that are difficult to control and interfere with day-to-day activities.
“The clinical improvement for many patients was more than double what we see with today’s standard of care,” Karlin said. “This occurred at all levels of anxiety, from moderate all the way up to severe.”
Standard of care for generalized anxiety disorder is a combination of cognitive behavioral therapy and medications such as selective serotonin reuptake inhibitors, or SSRIs, and buspirone — both of which work on levels of serotonin in the brain — as well as sedatives called benzodiazepines.
All of these medications need time to work and may require experimentation with various doses, adding time and expense to a patient’s treatment, Karlin said.
Determining proper dosage
The multicenter, randomized, double-blinded trial tested doses of 25, 50, 100 and 200 micrograms compared with a placebo.
“We’re very confident based on the results that 100 micrograms is the right dose to bring into our phase three studies, as we didn’t see any more improvement with 200 micrograms but did see additional adverse effects,” Karlin said.
Professor David Nutt, director of the Neuropsychopharmacology Unit at Imperial College London’s division of brain sciences, who researches psychedelics, said in an email that the study results “are very exciting data in what can be a difficult to treat population (anxiety).”
“They expand the likely utility of psychedelic treatment beyond depression,” said Nutt, who was not involved in the research. “And again, as with the depression trials, a single dose produces enduring effects, probable due to its breaking down persistent negative thought processes.”
While it was not the study’s primary purpose, results did show that MM120 also improved signs of depression, Karlin said. “We saw rapid and robust improvement on depression symptoms in people — depression and anxiety have overlapping disease definitions.”
No use of psychotherapy
Most research with MDMA and psilocybin has relied on the use of trained therapists who meet and establish a rapport with participants before the drug is administered. Those therapists are then on hand during the “trip” to help each person assimilate the experience, thus helping assure the lasting impact of any psychological insights.
The MM120 study, however, was accomplished without the use of psychotherapy during the session. Instead, monitors sat in the room to assure safety, but spent their time “mostly reading books,” Karlin said.
“While prior research has documented the benefits of combining LSD with psychotherapy to alleviate anxiety associated with life-threatening conditions, this groundbreaking study is the first to show that a single dose of LSD … can effectively treat generalized anxiety without the adjunct of psychotherapy,” said psychiatrist Dr. Gabriella Gobbi, a professor and scientist at McGill University Health Centre in Montreal and Canada Research Chair in Therapeutics for Mental Health. She was not involved in the clinical trial.
Compared with experiences with forms of LSD purchased illegally on the street, the study’s grade of MM120 did not appear to induce “bad trips,” Karlin said.
“LSD is difficult to manufacture with high purity and tends to degrade quickly in the presence of light and water,” Karlin said. “We’re manufacturing it to pharmaceutical industry standards, a highly pure version that is also shelf stable. So that’s a critical difference.”
Most adverse effects in the study were rated as mild to moderate by participants, occurring mostly on the day of the study, Karlin said. Those included euphoric feelings, illusions and hallucinations, anxiety, abnormal thinking, headaches, dizziness, nausea, excessive sweating, vomiting, numbness or tingling of the skin, and pupil dilation.
A long history of LSD research
When the MM120 clinical trial began in August 2022, it marked the first time LSD had been studied in a medical setting in over 40 years, Karlin said.
During the 1940s and early 1950s, tens of thousands of patients took LSD and other psychotropics to study their effects on cancer anxiety, alcoholism, opioid use disorder, depression, and post-traumatic stress disorder or PTSD. Researchers began to see psychedelics as possible “new tools for shortening psychotherapy.”
But when Harvard University psychologists Timothy Leary and Richard Alpert were fired from the Harvard Psilocybin Project in 1963 after the university discovered they had been giving LSD to their students, the use of psychedelics for research began to lose its luster.
Leary began to speak out publicly, encouraging young people to take LSD recreationally. He quickly became the face of the drug counterculture movement with his signature message, “Turn on, tune in, drop out.”
No longer administered solely in the relative safety of a lab or psychiatrist’s office, LSD began to feature in horror stories of bad “acid” trips at colleges and concerts — headlines that appeared alongside images of anti-Vietnam protests and Woodstock attendees.
In 1968, the United States outlawed LSD and research projects were shut down or forced underground. Then came the 1970 Controlled Substances Act, signed by President Richard Nixon. It classified all hallucinogenics, including psilocybin, as Schedule I drugs — substances with “no currently accepted medical use” and a high probability of abuse.
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 7, 2024 8:31:07 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 5, 2024 15:43:32 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 5, 2024 15:40:17 GMT -5
Tickets on sale FRI, 3/8 at Noon (12pm est)!
Brunch includes an all star farm-to-table meal by Pickle & Ash out of Stuart, VA + these beverages: coffee, mimosas and New Belgium Brewing beers.
In addition to brunch tickets, Rooster Walk 14 admission tickets are required to attend the brunch on Saturday in the New Belgium Brewing Pine Grove.
🥂 RW14 Brunch Info: roosterwalk.com/brunch
🎫 RW14 Tickets: roosterwalk.com/tickets/
🎉 Event info: roosterwalk.com
🧑🤝🧑 RSVP/ Invite friends: fb.me/e/12qk41Yte
🎧 Spotify Playlist: spoti.fi/3GFkzwo
🎶 More Shows: roosterwalk.com/upcoming-shows
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 5, 2024 15:27:37 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 5, 2024 13:28:20 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 5, 2024 8:21:49 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 4, 2024 21:25:25 GMT -5
So it will be interesting to see at the end how varied the set lists are once DeadCo wraps up. I'd expect different songs during a weekend, but the following weekend may be lather/rinse/repeat.
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 4, 2024 13:54:03 GMT -5
While it's not the bay bridge, I look forward to pulling Jonesville across this bridge each year on my way to Hatteras.
And you don't do anything special with the ez-pass to add the trailer (like suebhunny said?)
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 4, 2024 11:47:02 GMT -5
The Virginia ez-pass website isn't very clear on what I need to do with them, and other states seem to have different rules.
From the VA website, I'd think I need a new and separate transponder to use for just when I'm pulling the trailer and plan to go through tolls or bridges?
My first trip with it is going to be out to Cape Henlopen State park in a few weeks, which means crossing the bay bridge in MD. The Maryland ezpass site says to just add the trailer license plate to your account.
Virginia doesn't seem to allow that. The closest thing I see on the VA site is for 'SUV w/wo Trailer', but in the details it says 4 axles. I'll only have 3.
And I'm not going to lie, I know 18 wheelers cross the bay bridge all the time, and I've read its not an issue, but my butthole is a bit puckered up thinking about driving it across the bay bridge.
While it's not the bay bridge, I look forward to pulling Jonesville across this bridge each year on my way to Hatteras.
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 3, 2024 9:37:40 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 2, 2024 17:58:30 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 1, 2024 15:55:33 GMT -5
Good weekend to dewinterize those travel trailers if you haven't already. Tis the season...
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Mar 1, 2024 8:22:02 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Feb 29, 2024 12:06:53 GMT -5
Oh well, I guess I will have to stay with the unwashed masses.
Guess you'll get to try out your new generator(s).
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26
Cowboy Neal
If I could add one artist to the 2023 lineup: Dead and Company featuring Johnny Slayer
Number of LOCKNs attended: 7
Post by The Other One on Feb 29, 2024 10:45:44 GMT -5
Buy the ticket, take the ride...
the KIND 1/26
Dead Reckoning 1/27
Daniel Donato 2/3
St. Patty's Day Party 3/16
Del McCoury BAnd 4/25
About Time Music Festival 5/3-4
Rooster Walk 5/23-26
Floydfest 7/24-28
Yarnival 10/24-26